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Research

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Nupur Biswas

Sr. Scientist – Omics

March 20, 2024

Summary "Organ aging signatures in the plasma proteome track health and disease."

As we age our organs also age but not at the same rate. The onset and effects of aging vary from individual to individual. Animal studies showed aging varies within the organs of an individual also. As we age our cells undergo...

Organ aging
Shreya Puri

Data analyst intern

February 28, 2024

Summary "Longevity risk - Its financial impact on pensions."

The research explores the financial impacts of longevity risk on defined benefit (DB) pension plan liabilities in Ghana, utilizing data from the 2010 population census and the Lee-Carter model. It compares two key models...

Longevity and its financial impact
Yogita Dhas

Content writer – Clinical

February 21, 2024

Summary "Central nervous system health status as an important predictor of longevity."

The presentation emphasized the pivotal role of the central nervous system (CNS) health in determining longevity. Here's a concise summary of the key points covered...

Central nervous system
Arya CR

Data analyst intern

February 21, 2024

Summary "Social connectedness, functional capacity, and longevity: A focus on positive relations with others."

Longevity is amongst the complex traits whose genetic foundation is yet unknown. The purpose of this study was to investigate the possible causal relationship and genetic correlation between gut microbiota and...

Social connectedness, functional capacity, and longevit
Soumyadutta Basak

Jr. Bioinformatician

January 31, 2024

Summary "Association between gut microbiota, and longevity: A genetic correlation, and Mendelian randomization study."

Longevity is amongst the complex traits whose genetic foundation is yet unknown. The purpose of this study was to investigate the possible causal relationship and genetic correlation between gut microbiota and...

Gut microbiota
Nupur Biswas

Sr. Scientist – Omics

January 31, 2024

Summary "Lifespan or healthspan which is your goal?"

Lifespan refers to the time a person lives. On the other hand, healthspan refers to the time during which a person lives a healthy life without any chronic disease and age-related disorders. However, defining a healthy life...

Lifespan or healthspan
Vijay Padul

Sr. Scientist - Omics

January 24, 2024

Summary "Inherited components of longevity."

Aging and longevity has a strong genetic component. Every living organism is born with a set of genetic material that constitutes its genome. Humans inherit their genome and associated genetic traits from their parents.

Components of longevity
Yogita Dhas

Content writer – Clinical

January 17, 2024

Summary "Aging - What is it? How to prevent it?"

Aging is the time-related deterioration of physiological functions crucial for survival and fertility, marked by the gradual accumulation of cellular and molecular damage. It is a major risk factor for chronic diseases.

Aging and longevity
Chaya YK

Data analyst intern

January 17, 2024

Summary "Research on the prediction of longevity from both individual, and family perspectives."

This study addresses the growing challenges posed by population aging, particularly in China, where the proportion of elderly individuals has surged. With the elderly constituting a significant demographic, there's an increasing...

Prediction of longevity
Divyalakshmi

Content writer – Clinical

January 10, 2024

Summary "Healthy heart for healthy long life."

Life expectancy is a measure of population health. It is related to the longevity of an individual and is interdependent on a number of measurable factors. One of the most important factor is cardiovascular health.

Healthy heart
Nupur Biswas

Sr. Scientist – Omics

January 03, 2024

Summary "Longevity: How far can we stretch it?"

The basic question of longevity is how long a human can live. The increasing number of centenarians indicates an increase in the average lifespan. Till date, based on the available and reliable documents, the longest-living person was...

Longevity
Chiluveru Sruthi

Graphic designer

January 03, 2024

Summary "Genetic networks of Alzheimer's disease, aging and longevity in humans."

Since the 1970s, researchers have suggested that social networks, the connections people have in their daily lives, can impact health. The size, frequency of contact, and diversity of social networks have been...

Genetic networks of Alzheimer's disease
Vijay Padul

Sr. Scientist - Omics

December 27, 2023

Summary "Health informatics: Health and genetics data to predict longevity."

The desire to live a healthy long life has been a constant drive in search of solutions to achieve human longevity. With the advancement in medical science, successful treatment, and management of a large number of...

Health and genetics data to predict longevity
Isha Shaw

Data analyst intern

December 13, 2023

Summary "Social networks, social support, and life expectancy in older adults: The cardiovascular health study."

Since the 1970s, researchers have suggested that social networks, the connections people have in their daily lives, can impact health. The size, frequency of contact, and diversity of social networks have been...

Cardiovascular health study
Yogita Dhas

Content writer – Clinical

December 13, 2023

Summary "Physical and mental stress: Impact on lifespan."

Stress, whether physical or mental, plays a pivotal role in determining the quality and length of human life. Physical stress triggers predictable responses in tissues, organs, and systems, with chronic exposure leading to the...

Impact on lifespan
Yogita Dhas

Content writer – Clinical

December 06, 2023

Summary "Long-term impact of metformin and sulphonylurea therapies on type 2 diabetes: A two-decade analysis of survival patterns."

Metformin is a first-line drug used for type 2 diabetes (T2D) treatment. Metformin has been associated with other non-diabetic health benefits, such as extending a healthy lifespan, in addition to its main use in the treatment...

Long-term effects of metformin on longevity
Nupur Biswas

Sr. Scientist – Omics

November 29, 2023

Summary "Longevity: Determining factors."

The goal of the longevity research is understanding the aging process and tune it. For the quest of longevity, researchers identified nine hallmarks of aging which include genomic instability, telomere attrition...

Longevity determining factors
Vijay Padul

Sr. Scientist - Omics

November 22, 2023

Summary "Genomics: Can it answer longevity questions?"

Historically the attainment of healthy human longevity has remained a distant dream. With the advent of whole genome sequencing technology an entire genetic blueprint of the human can be elucidated in a short...

Genomics and longevity
Jay Darji

Jr. Technical researcher

November 22, 2023

Summary "DeepMAge: A methylation aging clock developed with deep learning."

Human longevity refers to the actual duration of an individual’s life, and it has been a subject of fascination, study, and speculation throughout human history. The quest for understanding and extending the human lifespan...

DeepMAge longevity
Vijay Padul

Sr. Scientist - Omics

November 15, 2023

Summary "A multicenter study uncovers genetic factors that may play a significant role in mice longevity."

Aging is a yet to be fully understood process where molecular, cellular, and organismal homeostasis is affected by multiple environmental and genetic factors which results in a progressive functional decline in physical...

Genetic factors of longevity
Nupur Biswas

Sr. Scientist – Omics

November 08, 2023

Summary "Gene transfer extends lifespan of mice."

Longer lifespan accompanied by healthy lifespan is always desired. Naked mole rats are the longest living rodents. They evolved efficient anti-aging and anti-cancer defense. Naked mole-rat tissues are highly...

Gene transfer | Longevity
Prathyusha

AWS and App developer

October 18, 2023

Summary "Deep learning-based six-type classifier for lung cancer, and mimics from histopathological whole slide images."

The development and application of deep learning techniques in the field of medical image analysis have seen significant advancements in recent years. One particularly promising area of research is the use of deep...

Lung Cancer
Sruthi Chiluveru

Graphic designer

October 04, 2023

Summary "Development of an eHealth tool for capturing and analyzing the immune-related adverse events (irAEs) in cancer treatment."

Immunotherapy is rapidly advancing and can now be considered a powerful new tool in the treatment of cancer. However, it is associated with a myriad of Immune-related adverse events (irAEs). These irAEs can affect numerous...

Lung cancer
Divyalakshmi

Content writer – Clinical

September 20, 2023

Summary "Artificial intelligence–based prediction of lung cancer risk using non-imaging electronic medical records: Deep learning approach."

Lung cancer is the most common cause of death worldwide. So, early detection is crucial which may be helpful to reduce mortality rate. Low-dose computed tomography (LDCT) screening may reduce the lung cancer...

Lung Cancer
Numair Arshad

Content writer – Clinical

September 13, 2023

Summary "Clinical trial shows potential of poziotinib for HER2-mutant lung cancer."

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for up to 85% of the patients. Around 3% of these NSCLC patients have mutations in the human epidermal growth factor receptor 2...

Non-Small-Cell Lung Cancer
J. Renuka Prasanna

Software engineer

September 06, 2023

Summary "An explainable machine learning framework for lung cancer hospital length of stay prediction."

The importance of predicting the length of stay (LOS) in the ICU for lung cancer patients is not well understood. This is because LOS can be used to manage hospital resources and improve patient outcomes. Traditional...

Lung cancer
Yogita Dhas

Content writer – Clinical

August 16, 2023

Summary "Easy-to-find irAEs can be used as indicators to predict neoadjuvant chemo-immunotherapy response."

Lung cancer is the prominent cause of cancer-related deaths worldwide. Non-small cell lung cancer (NSCLC) patients are diagnosed with early-stage disease in only 25% of cases, making them amenable to...

Easy-to-find irAEs can be used as indicators to predict neoadjuvant chemo-immunotherapy response.
Bharati Chundi

Content writer – Clinical

August 02, 2023

Summary "The efficacy and safety of albumin-bound paclitaxel plus carboplatin as neoadjuvant therapy for potentially resectable lung  squamous cell carcinoma: A real-world retrospective cohort study."

Lung cancer is the leading cause of cancer-related death. The most frequent forms of treatment for lung cancer include chemotherapy, radiotherapy, and surgery. The most common type of lung cancer is non-small cell...

The efficacy and safety of albumin-bound paclitaxel plus carboplatin as neoadjuvant therapy for pote
Jay Darji

Jr. Technical researcher

July 12, 2023

Summary "Lung cancer prediction using robust machine learning and image enhancement methods on extracted gray-level co-occurrence matrix features."

In the present era, cancer is the leading cause of demise in both men and women world-wide, with low survival rates due to inefficient diagnostic techniques. In the year 2021, about 1,898,160 new cancer cases were...

Lung cancer prediction using robust machine learning and image enhancement methods on extracted gray
Vijay Padul

Sr. Scientist - Omics

July 05, 2023

Summary "Nivolumab therapy in addition to chemotherapy improves survival in patients with resectable lung cancer."

Lung cancer is the third most common cancer in the United States. Over 80% of the total lung cancer cases belong to the type of non-small cell lung cancer (NSCLC). Among the patients diagnosed with...

Nivolumab therapy in addition to chemotherapy improves survival in patients with resectable lung can
Numair Arshad

Content writer – Clinical

June 28, 2023

Summary "Observation vs. radiosurgery: Which is best for asymptomatic meningiomas?"

Meningiomas are the most common intracranial tumors, accounting for almost 30% of all central nervous system (CNS) tumors in adults. A great majority of meningiomas are benign, correlating to grade I...

Observation vs. radiosurgery: Which is best for asymptomatic meningiomas
Nupur Biswas

Sr. Scientist – Omics

June 21, 2023

Summary "Role of air pollutants in lung cancer ."

Lung cancer in never-smokers (LCINS) is the eighth most common cause of cancer death in the UK. Such patients bear distinct clinical and molecular characteristics compared to lung cancer in smokers which...

Role of air pollutants in lung cancer
Divyalakshmi

Content writer – Clinical

May 31, 2023

Summary "A molecularly integrated grade for meningioma."

Meningiomas are one of the most common primary intracranial tumors in adults. Ass there is presence of more number of cases worldwide, there is a need for a reliable, widely accessible and acceptable predictor of...

A molecularly integrated grade for meningioma
Bharati Chundi

Content writer – Clinical

June 07, 2023

Summary "Somatostatin receptor theranostics for refractory meningiomas."

Meningiomas are non-cancerous lesions that arises from the membranes surrounding the brain and the spinal cord. They contribute to around 30% of the initial brain tumors and they are associated with different clinical...

Somatostatin Receptor Theranostics for Refractory Meningiomas
Numair Arshad

Content writer – Clinical

May 10, 2023

Summary "My experience with ChatGPT."

I spend my days learning about the mechanism of action of drugs and writing white papers, blogs, and short descriptions about diseases, as well as creating graphics that explain complex scientific concepts to a non-expert...

My experience with ChatGPT
Yogita Dhas

Content writer – Clinical

April 12, 2023

Summary "Phase 2 study of pembrolizumab in patients with recurrent and residual high-grade meningiomas."

Meningiomas are the most prevalent primary central nervous system tumor, with a prevalence of 170,000 cases in the United States. Maximal safe resection is the cornerstone of meningioma treatment, and...

Phase 2 study of pembrolizumab in patients with recurrent and residual high-grade meningiomas
Jay Darji

Jr. Technical researcher

March 29, 2023

Summary "A hybrid CNN-GLCM classifier for detection and grade classification of brain tumor."

A tumor is a volume of irregular and abnormal cells affecting the function of nearby healthy cells in the human body. Meningioma is the most commonly occurring tumor in adults with high-risk factors...

A hybrid CNN-GLCM classifier for detection and grade classification of brain tumor
Vijay Padul

Sr. Scientist - Omics

March 15, 2023

Summary "Multi-omic analysis of low-grade glioma histological subtypes uncovers the significance of tumor purity."

Astrocytoma and Oligodendroglioma are the histological subtypes of glioma brain tumors. Histological classification of gliomas has been the clinical practice before the inclusion of molecular markers by the...

Multi-omic analysis of low-grade glioma histological subtypes uncovers the significance of tumor pur
Isha Shaw

Proofreading intern

March 07, 2023

Summary "Quality of YouTube videos on meningioma treatment using the DISCERN instrument."

Meningiomas are the most common type of primary brain tumor that arises from the brain or the spinal cord. Although the majority of meningiomas are benign, these tumors can cause problems as they grow...

Quality of YouTube videos on meningioma treatment using the DISCERN instrument
Nupur Biswas

Sr. Scientist – Omics

March 01, 2023

Summary "Circular RNAs in Diagnosis of Astrocytoma."

Astrocytoma is a type of brain tumor associated with astrocytes. Grade IV astrocytoma is commonly known as glioblastoma. Molecular-based diagnosis is challenging as it requires brain surgery for obtaining...

Circular RNAs in Diagnosis of Astrocytoma
Bharati Chundi

Content writer – Clinical

February 15, 2023

Summary "Expression of CD133 cancer stems cell marker in IDH-mutant and IDH-wild type (isocitrate dehydrogenase) astrocytoma."

Astrocytoma is a tumor that arises from the astrocytes. They belong to a group called glial cells, the supporting cells seen in the central nervous system. They are specifically called astrocytes when they are...

Expression of  CD133 cancer stem cell marker in IDH-mutant and IDH-wild type (isocitrate dehydrogen
Divyalakshmi

Content writer – Clinical

February 08, 2023

Summary "Prognostic factors associated with survival in patients with diffuse astrocytoma."

Astrocytomas are the most common primary tumors in the central nervous system (CNS). These tumors arise from astrocytes—star-shaped cells that make up the “glue-like” or supportive tissue of the brain. The diagnosis is based...

Prognostic factors associated with survival in patients with diffuse astrocytoma
Aditi Ratnam

Proofreading intern

February 07, 2023

Summary "Brain tumor patients’ use of social media for disease management: Current practices and implications for the future."

Brain tumor-related diseases are some of the longest and most painful ailments worldwide, and their symptoms lead to social and physical isolation. This study is based on the patients who were administered a questionnaire...

Brain tumor patients’ use of social media for disease management: Current practices and implications
Numair Arshad

Content writer – Clinical

February 01, 2023

Summary "Exploring the safety and efficacy of a novel drug combination for treating recurrent high-grade astrocytomas: A phase 1 clinical trial."

Astrocytoma is a type of brain tumor that originates from star-shaped glial cells in the brain called astrocytes. According to the WHO classification, they are classified into four grades based on the degree of malignancy and...

Exploring the safety and efficacy of a novel drug combination for treating recurrent high-grade astr
Yogita Dhas

Content writer – Clinical

January 17, 2023

Summary "Grading of IDH‑mutant astrocytoma using diffusion, susceptibility, and perfusion‑weighted imaging."

The accurate grading of IDH-mutant astrocytoma is essential to develop therapeutic strategies and evaluating the prognosis of patients. A preoperative classification of these entities could be beneficial for the treatments...

Grading of IDH‑mutant astrocytoma using diffusion, susceptibility, and perfusion‑weighted imaging
Vijay Padul

Sr. Scientist - Omics

January 11, 2023

Summary "An effective integrated grading system for meningioma tumour grading that incorporates molecular features."

Meningioma is the most common primary intracranial tumor in the United States. There are approximately 35,000 new cases diagnosed every year. Meningioma has an estimated population prevalence of approximately...

An effective integrated grading system for meningioma tumour grading that incorporates molecular fea
Aditi Ratnam

Proofreading intern

January 10, 2023

Summary "How mental health care should change as a consequence of the COVID-19 pandemic?"

As the world went from having the busiest streets to empty ones, lives were changed all around in 2020. The coronavirus or Covid-19 more formally known as SARS-CoV-2 was first discovered in Wuhan, China in December...

How mental health care should change as a consequence of the COVID-19 pandemic
Abhijeet Chavan

Jr. Economist intern

December 20, 2022

Summary "Caste differences in hypertension among women in India: Diminishing health returns to socioeconomic status for lower caste groups."

The caste system is a relatively rigid system of social hierarchy in India. Caste membership defines one’s access to resources and life opportunities. A growing body of research suggests that lower caste...

Caste differences in hypertension among women in India: diminishing health returns to socioeconomic
Ishita Narvekar

Jr. Economist intern

December 13, 2022

Summary "Dietary intake of Parkinson's disease patients."

Parkinson's disease is the second most prevalent neurodegenerative disorder. Often, dietary management is supplemented as adjuvant therapy. Therefore, dietary relevant studies may grant an interesting...

Dietary intake of Parkinson's disease patients
Jay Darji

Jr. Technical researcher

November 16, 2022

Summary "A comparative analysis of machine learning algorithms to predict Alzheimer’s disease."

Alzheimer's disease is a progressive neurological disorder that causes brain cells to die and the brain to shrink (atrophy). Alzheimer's disease is the most common cause of dementia, which is defined as a progressive decline...

A comparative analysis of machine learning algorithms to predict Alzheimer’s disease
Bharati Chundi

Content writer – Clinical

November 09, 2022

Summary "High frequency of psychosis in late-stage Parkinson's disease."

Parkinson’s disease (PD) is a neurological disorder observed mostly in elderly individuals. The symptoms include tremors, muscle stiffness, slow motion, and loss of balance. It is caused when neurons of the basal ganglia region...

High frequency of psychosis in late-stage Parkinsońs disease
Divyalakshmi

Content writer – Clinical

November 02, 2022

Summary "Reassessing diabetes and APOE genotype as potential interacting risk factors for Alzheimer’s disease."

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder in which the death of brain cells causes memory loss and cognitive decline. Alzheimer's disease is the most common cause of dementia...

Reassessing Diabetes and APOE Genotype as Potential Interacting Risk Factors for Alzheimer’s disease
Aditi Ratnam

Proofreading intern

November 01, 2022

Summary "YouTube as a source of information for neurosurgery."

Social Media is an important part of our daily lives; statistically, it has been so for the last two centuries. We have evolved from the invention of the telegraph in 1844 (where messages were transmitted physically...

YouTube as a Source of Information for Neurosurgery
Numair Arshad

Content writer – Clinical

October 25, 2022

Summary "Slowing down Alzheimer’s disease by combining an anti-oxidant drug, GV1001, with donepezil."

Alzheimer’s disease (AD) is a neurodegenerative disease that impairs short-term memory and affects the judgment and behavior of the patient. Brain cells continue to die as time passes and the patient eventually...

Slowing down Alzheimer’s disease by combining an anti-oxidant drug, GV1001, with donepezil
Nupur Biswas

Sr. Scientist – Omics

October 19, 2022

Summary "Identifying candidate Parkinson's disease genes by integrating genomic data."

Parkinson’s disease (PD) is a neurological disorder observed mostly in elderly individuals. The symptoms include tremors, muscle stiffness, slow motion, and loss of balance. It is caused when neurons...

Identifying candidate Parkinson's disease genes by integrating genomic data
Yogita Dhas

Content writer – Clinical

October 18, 2022

Summary "A six-metabolite panel as potential blood-based biomarkers for Parkinson’s disease."

Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease (AD) and affects around five million people worldwide. People with PD typically exhibit symptoms when 50% or more...

A six-metabolite panel as potential blood-based biomarkers for Parkinson’s disease
Jhivir Kapoor

Jr. Economist intern

October 12, 2022

Summary "Economic burden of Alzheimer’s disease dementia in Japan."

Alzheimer’s disease dementia (ADD) is the leading cause of long-term care in Japan. In Japan, the number of older adults aged 65 years or over, living with dementia was estimated to be 4,620,000 in 2012. In a projection using data...

Economic Burden of Alzheimer’s Disease Dementia in Japan
Shaheen Shah

Content writer – Clinical

October 11, 2022

Summary "Triggers and alleviating factors for fatigue in Parkinson's disease."

Parkinson's disease (PD) is a progressive disorder that affects the nervous system. Symptoms start slowly. The first symptom may be a barely noticeable tremor in just one hand. Tremors are typical, but the disorder...

Triggers and alleviating factors for fatigue in Parkinson's disease
Vijay Padul

Sr. Scientist - Omics

October 07, 2022

Summary "Uncovering the link between chromatin activity, gene expression in myeloid cells and Alzheimer’s disease risk."

Alzheimer’s disease (AD) is a progressive neurological disorder commonly affecting people older than 65 years of age. The neurodegenerative progression of the disorder...

Uncovering the link between chromatin activity, gene expression in myeloid cells and Alzheimer’s disease risk.
Nupur Biswas

Sr. Scientist – Omics

September 14, 2022

Summary "Somatic mutations in Alzheimer’s disease neurons."

Alzheimer’s disease (AD) is a common age-associated neurodegenerative disorder. It is associated with the deposition of amyloid-beta oligomers and tau proteins. However, the underneath cellular dysfunction is...

Somatic mutations in Alzheimer’s disease neurons
Ishita Narvekar

Jr. Economist intern

September 28, 2022

Summary "Association of multidimensional poverty with dementia in adults aged 50 years or older in South Africa."

Dementia has become a global health challenge. It is well documented that poor social determinants of health are directly associated with the disease. Hence a multidimensional approach to poverty...

Association of multidimensional poverty with dementia in adults aged 50 years or older in South Africa
Sowmya Shivarama

Content writer – Clinical

August 19, 2022

Summary "Targeting the αv integrin/TGF-β axis improves natural killer cell function against glioblastoma stem cells."

Glioblastoma multiform (GBM), the most aggressive brain cancer, recurs due to the resistance of glioblastoma stem cells (GSCs) to all standard therapies. This dismal therapy outcome has sparked intense interest in immunotherapy...

Glioblastoma Multiforme -SS.jpg
Abhijeet Chavan

Jr. Economist intern

September 21, 2022

Summary "Caste, religion, and mental health in India"

A large, multi-disciplinary literature in social epidemiology, public health, and medical sociology has been concerned with documenting and understanding disparities in health by race, ethnicity, gender, socioeconomic...