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Phase 2 study of pembrolizumab in patients with recurrent and residual high-grade meningiomas | CellTalk
Meningiomas are the most prevalent primary central nervous system tumor, with a prevalence of 170,000 cases in the United States. Maximal safe resection is the cornerstone of meningioma treatment, and adjuvant radiation may be necessary...
A hybrid CNN-GLCM classifier for detection and grade classification of brain tumour | CellTalk
A tumor is a volume of irregular and abnormal cells affecting the function of nearby healthy cells in the human body. Meningioma is the most commonly occurring tumor in adults with high-risk factors. Meningiomas are seen in the...
Multi-omic analysis of low-grade glioma histological subtypes uncovers the significance of tumor purity | CellTalk
Astrocytoma and Oligodendroglioma are the histological subtypes of glioma brain tumors. Histological classification of gliomas has been the clinical practice before the inclusion of molecular markers by the World Health Organization (WHO) Classification...
Quality of YouTube videos on meningioma treatment using the DISCERN instrument | CellTalk
Meningiomas are the most common type of primary brain tumor that arises from the brain or the spinal cord. Although the majority of meningiomas are benign, these tumors can cause problems as they grow and compress against...
Circular RNAs in Diagnosis of Astrocytoma | CellTalk
Astrocytoma is a type of brain tumor associated with astrocytes. Grade IV astrocytoma is commonly known as glioblastoma. Molecular-based diagnosis is challenging as it requires brain surgery for obtaining tissue samples/specimens...
Expression of CD133 cancer stem cell marker in IDH-mutant and IDH-wild type (isocitrate dehydrogenase) astrocytoma | CellTalk
Astrocytoma is a tumor that arises from the astrocytes. They belong to a group called glial cells, the supporting cells seen in the central nervous system. They are specifically called astrocytes when they are restricted to...
Prognostic factors associated with survival in patients with diffuse astrocytoma | CellTalk
Astrocytomas are the most common primary tumors in the central nervous system (CNS). These tumors arise from astrocytes—star-shaped cells that make up the “glue-like” or supportive tissue of the brain. The diagnosis is based primarily on...
Brain tumour patients’ use of social media for disease management: Current practices and implications for the future | CellTalk
Brain tumor-related diseases are some of the longest and most painful ailments worldwide, and their symptoms lead to social and physical isolation. This study is based on the patients who were administered a questionnaire on an electronic...
Exploring the safety and efficacy of a novel drug combination for treating recurrent high-grade astrocytomas: A phase 1 clinical trial | CellTalk
Astrocytoma is a type of brain tumor that originates from star-shaped glial cells in the brain called astrocytes. According to the WHO classification, they are classified into four grades based on the degree of malignancy and...
Grading of IDH‑mutant astrocytoma using diffusion, susceptibility, and perfusion‑weighted imaging | CellTalk
The accurate grading of IDH-mutant astrocytoma is essential to develop therapeutic strategies and evaluating the prognosis of patients. A preoperative classification of these entities could be beneficial for the treatments of patients, particularly in those...
An effective integrated grading system for meningioma tumour grading that incorporates molecular features | CellTalk
Meningioma is the most common primary intracranial tumor in the United States. There are approximately 35,000 new cases diagnosed every year. Meningioma has an estimated population prevalence of approximately 1 in every 100 adult persons...
How mental health care should change as a consequence of the COVID-19 pandemic | CellTalk
As the world went from having the busiest streets to empty ones, lives were changed all around in 2020. The coronavirus or Covid-19 more formally known as SARS-CoV-2 was first discovered in Wuhan, China in December 2019. Shortly after it was declared an...
Caste differences in hypertension among women in India: diminishing health returns to socioeconomic status for lower caste groups | CellTalk
The caste system is a relatively rigid system of social hierarchy in India. Caste membership defines one’s access to resources and life opportunities. A growing body of research suggests that lower caste groups have an excess burden of morbidity and...
Dietary intake of Parkinson's disease patients | CellTalk
Parkinson's disease is the second most prevalent neurodegenerative disorder. Often, dietary management is supplemented as adjuvant therapy. Therefore, dietary-relevant studies may grant an interesting insight into the diet of PD...
A comparative analysis of machine learning algorithms to predict Alzheimer’s disease | CellTalk
Alzheimer's disease is a progressive neurological disorder that causes brain cells to die and the brain to shrink (atrophy). Alzheimer's disease is the most common cause of dementia, which is defined as a progressive decline...
High frequency of psychosis in late-stage Parkinson's disease | CellTalk
Parkinson’s disease (PD) is a neurological disorder observed mostly in elderly individuals. The symptoms include tremors, muscle stiffness, slow motion, and loss of balance. It is caused when neurons of the basal ganglia region...
Reassessing Diabetes and APOE Genotype as Potential Interacting Risk Factors for Alzheimer’s disease | CellTalk
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder in which the death of brain cells causes memory loss and cognitive decline. Alzheimer's disease is the most common cause of dementia — a continuous decline in thinking, behavioral...
YouTube as a Source of Information for Neurosurgery | CellTalk
Social Media is an important part of our daily lives; statistically, it has been so for the last two centuries. We have evolved from the invention of the telegraph in 1844 (where messages were transmitted physically...
Slowing down Alzheimer’s disease by combining an anti-oxidant drug, GV1001, with donepezil | CellTalk
Alzheimer’s disease (AD) is a neurogenerative disease that impairs short-term memory and affects the judgment and behavior of the patient. Brain cells continue to die as time passes and the patient eventually becomes dependent on...
Identifying candidate Parkinson's disease genes by integrating genomic data | CellTalk
Parkinson’s disease (PD) is a neurological disorder observed mostly in elderly individuals. The symptoms include tremors, muscle stiffness, slow motion, and loss of balance. It is caused when neurons of the basal ganglia region of the brain fail to...
A six-metabolite panel as potential blood-based biomarkers for Parkinson’s disease | CellTalk
Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease (AD) and affects around five million people worldwide. People with PD typically exhibit symptoms when 50% or more...
Economic Burden of Alzheimer’s Disease Dementia in Japan | CellTalk
Alzheimer’s disease dementia (ADD) is the leading cause of long-term care in Japan. In Japan, the number of older adults aged 65 years or over, living with dementia was estimated to be 4,620,000 in 2012. In a projection using data from a dementia study...
Triggers and alleviating factors for fatigue in Parkinson's disease | CellTalk
Parkinson's disease (PD) is a progressive disorder that affects the nervous system. Symptoms start slowly. The first symptom may be a barely noticeable tremor in just one hand. Tremors are typical, but the disorder may also cause stiffness...
Uncovering the link between chromatin activity, gene expression in myeloid cells and Alzheimer’s disease risk | CellTalk
Alzheimer’s disease (AD) is a progressive neurological disorder commonly affecting people older than 65 years of age. The neurodegenerative progression of the disorder causes the death of the brain cells which results in brain atrophy...
Association of multidimensional poverty with dementia in adults aged 50 years or older in SA | CellTalk
Dementia has become a global health challenge. It is well documented that poor social determinants of health are directly associated with the disease. Hence a multidimensional approach to poverty...
Caste, religion, and mental health in India | CellTalk
A large, multi-disciplinary literature in social epidemiology, public health, and medical sociology has been concerned with documenting and understanding disparities in health by race, ethnicity, and gender...
Somatic mutations in Alzheimer’s disease neurons | CellTalk
Alzheimer’s disease (AD) is a common age-associated neurodegenerative disorder. It is associated with the deposition of amyloid-beta oligomers and tau proteins. However, the underneath cellular dysfunction...
Targeting the αv integrin/TGF-β axis improves natural killer cell function against Glioblastoma stem cells | CellTalk
Glioblastoma multiform (GBM), the most aggressive brain cancer, recurs due to the resistance of glioblastoma stem cells (GSCs) to all standard therapies. This dismal therapy outcome has sparked intense interest in immunotherapy as a means of...
Comparing the average cost of outpatient care of public and for-profit private providers in India | CellTalk
In mixed healthcare systems like India's, it is crucial to understand the cost of care associated with various types of healthcare providers to influence policy discussions. Existing studies reporting Out of Pocket Expenditure (OOPE) per episode of...
Slowing down glioma growth by knocking out miR-21 in mice models | CellTalk
Glioblastoma multiforme (GBM) is an aggressive form of glioma with a median survival of 15 months. Heterogeneity is one of the main characteristics of GBM. The tumor cells show variability not only from one patient to another but within the...
Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma | CellTalk
Glioblastoma multiforme (GBM) is the most common and aggressive form of primary brain cancer in adults. It accounts for about 60-70% of gliomas. The standard treatment regimen for GBM is tumor resection followed by radiotherapy...
Health and its Impact on Economic Growth in India – An Explanation | CellTalk
The role of ‘human capital’ in economic growth is vital. An economy that depends on human capital is now widely accepted. A higher level of human capital is the result of a higher level of health status, better health education, new learning, and...
Targeted therapeutics on Glioblastoma Multiforme | CellTalk
Glioblastoma (GBM) is the malignant brain tumor of the primary central nervous system arising from the glial cells having an incidence ranging from 5 to 8 persons per 100,000 people. The median survival duration is around 12 to 18 months with the...
A phase Ib-IIa trial of 9 repurposed drugs combined with temozolomide for the treatment of recurrent glioblastoma- CUSP9v3-2021 | CellTalk
Glioblastoma is the most common and most aggressive primary malignant brain tumor in adults. Despite therapeutic interventions, the glioblastoma prognosis remains very poor as most patients die within 12 months after diagnosis...
EGFR status determines GB subtypes | CellTalk
Glioblastoma (GB) multiforme, IDH wild-type (GB-IDHwt) is the most frequent brain tumor with a poor survival rate. Glioblastoma with mutant IDH enzyme shows a good prognosis. The highly genetic heterogeity is responsible for the absence of...
Effects of metformin as add-on therapy against Glioblastoma: an old medicine for novel oncology therapeutics | CellTalk
Medical research is all about finding evidence-based solutions for healthcare through diligent and innovative technologies. Every published paper holds a stepping stone for the next innovations. With the improvement of medical science...
