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Aging - What is it? How to prevent it? | CellTalk

This presentation elaborates on the relationship between calorie restriction and its potential impact on aging processes. Aging is defined as the time-related deterioration of physiological functions, posing a major risk for chronic diseases. Hallmarks...

Research on the prediction of longevity from both individual and family perspectives | CellTalk

This study addresses the growing challenges posed by population aging, particularly in China, where the proportion of elderly individuals has surged. With the elderly constituting a significant demographic, there's an increasing...

Longevity: How far can we stretch it? | CellTalk

The most appealing question of longevity is how long a human can live. The reported maximum age of humans is 122 years. The demographic data shows that the maximum reported age at death (MRAD) decreases after...

Health informatics: Health and genetics data to predict longevity | CellTalk

The desire to live a healthy long life has been a constant drive in search of solutions to achieve human longevity. With the advancement in medical science, successful treatment, and management of a large number of diseases has become...

Genetic networks of Alzheimer's disease, Aging and longevity in humans | CellTalk

Human genomic analysis and genome-wide association studies (GWAS) have identified genes that are risk factors for early and late-onset Alzheimer’s disease (AD genes). Prior research has concentrated on a particular group of genes that have...

Social networks, social support, and life expectancy in older adults: the cardiovascular health study | CellTalk

Since the 1970s, researchers have suggested that social networks, the connections people have in their daily lives, can impact health. The size, frequency of contact, and diversity of social networks have been linked to health effects. Smaller social networks...

Physical and mental stress: Impact on lifespan | CellTalk

This presentation explores the intricate relationship between physical and mental stress and their potential impact on human lifespan. Delving into the physiological effects of chronic physical stress, it elucidates how stress hormones like...

Long-term impact of metformin and sulphonylurea therapies on type 2 diabetes: A two-decade analysis of survival patterns | CellTalk

Metformin is a first-line drug used for type 2 diabetes (T2D) treatment. Metformin has been associated with other non-diabetic health benefits, such as extending a healthy lifespan, in addition to its main use in the treatment of...

Longevity: Determining factors | CellTalk

The goal of the longevity research is understanding the aging process and tune it. For the quest of longevity, researchers identified nine hallmarks of aging which include genomic instability, telomere attrition...

Genomics: Can it answer longevity questions? | CellTalk

Historically the attainment of healthy human longevity has remained a distant dream. With the advent of whole genome sequencing technology, an entire genetic blueprint of the human can be elucidated in a short time. The increased resolution...

DeepMAge: A Methylation Aging Clock Developed with Deep learning | CellTalk

Human longevity refers to the actual duration of an individual’s life, and it has been a subject of fascination, study, and speculation throughout human history. The quest for understanding and extending the human lifespan has driven scientific research...

A multicenter study uncovers genetic factors that may play a significant role in mice longevity | CellTalk

Aging is a yet to be fully understood process where molecular, cellular, and organismal homeostasis is affected by multiple environmental and genetic factors which results in progressive functional decline in physical, mental, and reproductive...

Gene transfer extends lifespan of mice | CellTalk

Longer lifespan accompanied by healthy lifespan is always desired. Naked mole rats are the longest living rodents. They evolved efficient anti-aging and anti-cancer defense. Naked mole-rat tissues are highly enriched for high molecular weight hyaluronic...

Deep learning-based six-type classifier for lung cancer and mimics from histopathological whole slide images | CellTalk

The development and application of deep learning techniques in the field of medical image analysis have seen significant advancements in recent years. One particularly promising area of research is the use of deep learning-based...

Development of an eHealth tool for capturing and analyzing the immune-related adverse events (irAEs) in cancer treatment | CellTalk

Immunotherapy is rapidly advancing and can now be considered a powerful new tool in the treatment of cancer. However, it is associated with a myriad of Immune-related adverse events (irAEs). These irAEs can affect numerous body organs and are potentially...

AI-based prediction of Lung cancer risk using non-imaging electronic medical records: deep learning approach | CellTalk

Lung cancer is the most common cause of death worldwide. So, early detection is crucial which may be helpful to reduce mortality rate. Low-dose computed tomography (LDCT) screening may reduce lung cancer-associated mortality...

Clinical trial shows potential of poziotinib for HER2-mutant lung cancer | CellTalk

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for up to 85% of the patients. Around 3% of these NSCLC patients have mutations in the human epidermal growth factor receptor 2 (ERBB2, HER2) gene...

An explainable machine learning framework for lung cancer hospital length of stay prediction | CellTalk

The importance of predicting the length of stay (LOS) in the ICU for lung cancer patients is not well understood. This is because LOS can be used to manage hospital resources and improve patient outcomes. Traditional LOS calculation methods are...

Easy-to-find irAEs can be used as indicators to predict neoadjuvant chemo-immunotherapy response | CellTalk

Lung cancer is the prominent cause of cancer-related deaths worldwide. Non-small cell lung cancer (NSCLC) patients are diagnosed with early-stage disease in only 25% of cases, making them amenable to surgery with a curative goal. The development...

The efficacy and safety of albumin-bound paclitaxel plus carboplatin as neoadjuvant therapy for potentially resectable lung  squamous cell carcinoma: a real-world retrospective cohort study | CellTalk

Lung cancer is the leading cause of cancer-related death. The most frequent forms of treatment for lung cancer include chemotherapy, radiotherapy, and surgery. The most common type of lung cancer is non-small cell lung cancer (NSCLC) which contributes to...

Lung cancer prediction using robust machine learning and image enhancement methods on extracted gray-level co-occurrence matrix features | CellTalk

In the present era, cancer is the leading cause of demise in both men and women world-wide, with low survival rates due to inefficient diagnostic techniques. In the year 2021, about 1,898,160 new cancer cases were encountered, and 608,570 deaths...

Nivolumab therapy in addition to chemotherapy improves survival in patients with resectable lung cancer | CellTalk

Lung cancer is the third most common cancer in the United States. Over 80% of the total lung cancer cases belong to the type non-small cell lung cancer (NSCLC). Among the patients diagnosed with NSCLC, ~20 to 25% have resectable cancer. Patients with...

Observation vs. radiosurgery: Which is best for asymptomatic meningiomas | CellTalk

Meningiomas are the most common intracranial tumors, accounting for almost 30% of all central nervous system (CNS) tumors in adults. A great majority of meningiomas are benign, correlating to grade I of World Health Organization...

Lung adenocarcinoma promotion by air pollutants | CellTalk

Lung cancer in never-smokers (LCINS) is the eighth most common cause of cancer death in the UK. Such patients bear distinct clinical and molecular characteristics compared to lung cancer in smokers which include EGFR mutations. The current...

A molecularly integrated grade for meningioma | CellTalk

Meningiomas are one of the most common primary intracranial tumors in adults. As there is a presence of more number of cases worldwide, there is a need for a reliable, widely accessible, and acceptable predictor of clinical outcome after...

Somatostatin receptor theranostics for refractory Meningiomas | CellTalk

Meningiomas are non-cancerous lesions that arises from the membranes surrounding the brain and the spinal cord. They contribute to around 30% of the initial brain tumors and they are associated with different clinical outcomes. About 80% of...

My experience with ChatGPT | CellTalk

I spend my days learning about the mechanism of action of drugs and writing white papers, blogs, and short descriptions about diseases, as well as creating graphics that explain complex scientific concepts to a non-expert...

Phase 2 study of pembrolizumab in patients with recurrent and residual high-grade meningiomas | CellTalk

Meningiomas are the most prevalent primary central nervous system tumor, with a prevalence of 170,000 cases in the United States. Maximal safe resection is the cornerstone of meningioma treatment, and adjuvant radiation may be necessary...

A hybrid CNN-GLCM classifier for detection and grade classification of brain tumour | CellTalk

A tumor is a volume of irregular and abnormal cells affecting the function of nearby healthy cells in the human body. Meningioma is the most commonly occurring tumor in adults with high-risk factors. Meningiomas are seen in the...

Multi-omic analysis of low-grade glioma histological subtypes uncovers the significance of tumor purity | CellTalk

Astrocytoma and Oligodendroglioma are the histological subtypes of glioma brain tumors. Histological classification of gliomas has been the clinical practice before the inclusion of molecular markers by the World Health Organization (WHO) Classification...

Quality of YouTube videos on meningioma treatment using the DISCERN instrument | CellTalk

Meningiomas are the most common type of primary brain tumor that arises from the brain or the spinal cord. Although the majority of meningiomas are benign, these tumors can cause problems as they grow and compress against...

Circular RNAs in Diagnosis of Astrocytoma | CellTalk

Astrocytoma is a type of brain tumor associated with astrocytes. Grade IV astrocytoma is commonly known as glioblastoma. Molecular-based diagnosis is challenging as it requires brain surgery for obtaining tissue samples/specimens...

​Expression of   CD133 cancer stem cell marker in IDH-mutant and IDH-wild type (isocitrate dehydrogenase) astrocytoma | CellTalk

Astrocytoma is a tumor that arises from the astrocytes. They belong to a group called glial cells, the supporting cells seen in the central nervous system. They are specifically called astrocytes when they are restricted to...

Prognostic factors associated with survival in patients with diffuse astrocytoma | CellTalk

Astrocytomas are the most common primary tumors in the central nervous system (CNS). These tumors arise from astrocytes—star-shaped cells that make up the “glue-like” or supportive tissue of the brain. The diagnosis is based primarily on...

Brain tumour patients’ use of social media for disease management: Current practices and implications for the future | CellTalk

Brain tumor-related diseases are some of the longest and most painful ailments worldwide, and their symptoms lead to social and physical isolation. This study is based on the patients who were administered a questionnaire on an electronic...

Exploring the safety and efficacy of a novel drug combination for treating recurrent high-grade astrocytomas: A phase 1 clinical trial | CellTalk

Astrocytoma is a type of brain tumor that originates from star-shaped glial cells in the brain called astrocytes. According to the WHO classification, they are classified into four grades based on the degree of malignancy and...

Grading of IDH‑mutant astrocytoma using diffusion, susceptibility, and perfusion‑weighted imaging | CellTalk

The accurate grading of IDH-mutant astrocytoma is essential to develop therapeutic strategies and evaluating the prognosis of patients. A preoperative classification of these entities could be beneficial for the treatments of patients, particularly in those...

An effective integrated grading system for meningioma tumour grading that incorporates molecular features | CellTalk

Meningioma is the most common primary intracranial tumor in the United States. There are approximately 35,000 new cases diagnosed every year. Meningioma has an estimated population prevalence of approximately 1 in every 100 adult persons...

How mental health care should change as a consequence of the COVID-19 pandemic | CellTalk

As the world went from having the busiest streets to empty ones, lives were changed all around in 2020. The coronavirus or Covid-19 more formally known as SARS-CoV-2 was first discovered in Wuhan, China in December 2019. Shortly after it was declared an...

Caste differences in hypertension among women in India: diminishing health returns to socioeconomic status for lower caste groups | CellTalk

The caste system is a relatively rigid system of social hierarchy in India. Caste membership defines one’s access to resources and life opportunities. A growing body of research suggests that lower caste groups have an excess burden of morbidity and...

Dietary intake of Parkinson's disease patients | CellTalk

Parkinson's disease is the second most prevalent neurodegenerative disorder. Often, dietary management is supplemented as adjuvant therapy. Therefore, dietary-relevant studies may grant an interesting insight into the diet of PD...

A comparative analysis of machine learning algorithms to predict Alzheimer’s disease | CellTalk

Alzheimer's disease is a progressive neurological disorder that causes brain cells to die and the brain to shrink (atrophy). Alzheimer's disease is the most common cause of dementia, which is defined as a progressive decline...

High frequency of psychosis in late-stage Parkinson's disease | CellTalk

Parkinson’s disease (PD) is a neurological disorder observed mostly in elderly individuals. The symptoms include tremors, muscle stiffness, slow motion, and loss of balance. It is caused when neurons of the basal ganglia region...

Reassessing Diabetes and APOE Genotype as Potential Interacting Risk Factors for Alzheimer’s disease | CellTalk

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder in which the death of brain cells causes memory loss and cognitive decline. Alzheimer's disease is the most common cause of dementia — a continuous decline in thinking, behavioral...

YouTube as a Source of Information for Neurosurgery | CellTalk

Social Media is an important part of our daily lives; statistically, it has been so for the last two centuries. We have evolved from the invention of the telegraph in 1844 (where messages were transmitted physically...

Slowing down Alzheimer’s disease by combining an anti-oxidant drug, GV1001, with donepezil | CellTalk

Alzheimer’s disease (AD) is a neurogenerative disease that impairs short-term memory and affects the judgment and behavior of the patient. Brain cells continue to die as time passes and the patient eventually becomes dependent on...

Identifying candidate Parkinson's disease genes by integrating genomic data | CellTalk

Parkinson’s disease (PD) is a neurological disorder observed mostly in elderly individuals. The symptoms include tremors, muscle stiffness, slow motion, and loss of balance. It is caused when neurons of the basal ganglia region of the brain fail to...

A six-metabolite panel as potential blood-based biomarkers for Parkinson’s disease | CellTalk

Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease (AD) and affects around five million people worldwide. People with PD typically exhibit symptoms when 50% or more...

Economic Burden of Alzheimer’s Disease Dementia in Japan | CellTalk

Alzheimer’s disease dementia (ADD) is the leading cause of long-term care in Japan. In Japan, the number of older adults aged 65 years or over, living with dementia was estimated to be 4,620,000 in 2012. In a projection using data from a dementia study...

Triggers and alleviating factors for fatigue in Parkinson's disease | CellTalk

Parkinson's disease (PD) is a progressive disorder that affects the nervous system. Symptoms start slowly. The first symptom may be a barely noticeable tremor in just one hand. Tremors are typical, but the disorder may also cause stiffness...

Uncovering the link between chromatin activity, gene expression in myeloid cells and Alzheimer’s disease risk | CellTalk

Alzheimer’s disease (AD) is a progressive neurological disorder commonly affecting people older than 65 years of age. The neurodegenerative progression of the disorder causes the death of the brain cells which results in brain atrophy...

Association of multidimensional poverty with dementia in adults aged 50 years or older in SA | CellTalk

Dementia has become a global health challenge. It is well documented that poor social determinants of health are directly associated with the disease. Hence a multidimensional approach to poverty...

Caste, religion, and mental health in India | CellTalk

A large, multi-disciplinary literature in social epidemiology, public health, and medical sociology has been concerned with documenting and understanding disparities in health by race, ethnicity, and gender...

Somatic mutations in Alzheimer’s disease neurons | CellTalk

Alzheimer’s disease (AD) is a common age-associated neurodegenerative disorder. It is associated with the deposition of amyloid-beta oligomers and tau proteins. However, the underneath cellular dysfunction...

Targeting the αv integrin/TGF-β axis improves natural killer cell function against Glioblastoma stem cells | CellTalk

Glioblastoma multiform (GBM), the most aggressive brain cancer, recurs due to the resistance of glioblastoma stem cells (GSCs) to all standard therapies. This dismal therapy outcome has sparked intense interest in immunotherapy as a means of...

Comparing the average cost of outpatient care of public and for-profit private providers in India | CellTalk

In mixed healthcare systems like India's, it is crucial to understand the cost of care associated with various types of healthcare providers to influence policy discussions. Existing studies reporting Out of Pocket Expenditure (OOPE) per episode of...

Slowing down glioma growth by knocking out miR-21 in mice models | CellTalk

Glioblastoma multiforme (GBM) is an aggressive form of glioma with a median survival of 15 months. Heterogeneity is one of the main characteristics of GBM. The tumor cells show variability not only from one patient to another but within the...

Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma | CellTalk

Glioblastoma multiforme (GBM) is the most common and aggressive form of primary brain cancer in adults. It accounts for about 60-70% of gliomas. The standard treatment regimen for GBM is tumor resection followed by radiotherapy...

Health and its Impact on Economic Growth in India – An Explanation | CellTalk

The role of ‘human capital’ in economic growth is vital. An economy that depends on human capital is now widely accepted. A higher level of human capital is the result of a higher level of health status, better health education, new learning, and...

Targeted therapeutics on Glioblastoma Multiforme | CellTalk

Glioblastoma (GBM) is the malignant brain tumor of the primary central nervous system arising from the glial cells having an incidence ranging from 5 to 8 persons per 100,000 people. The median survival duration is around 12 to 18 months with the...

A phase Ib-IIa trial of 9 repurposed drugs combined with temozolomide for the treatment of recurrent glioblastoma- CUSP9v3-2021 | CellTalk

Glioblastoma is the most common and most aggressive primary malignant brain tumor in adults. Despite therapeutic interventions, the glioblastoma prognosis remains very poor as most patients die within 12 months after diagnosis...

EGFR status determines GB subtypes | CellTalk

Glioblastoma (GB) multiforme, IDH wild-type (GB-IDHwt) is the most frequent brain tumor with a poor survival rate. Glioblastoma with mutant IDH enzyme shows a good prognosis. The highly genetic heterogeity is responsible for the absence of...

Effects of metformin as add-on therapy against Glioblastoma: an old medicine for novel oncology therapeutics | CellTalk

Medical research is all about finding evidence-based solutions for healthcare through diligent and innovative technologies. Every published paper holds a stepping stone for the next innovations. With the improvement of medical science...

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